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Makise Medical Center
With proper guidelines, supplements, ointments, and treatment, you can be free from psoriasis within four months.
I am not a dermatologist but a general physician. I see psoriasis as an inside-out disease which is a different view from the ordinary dermatologists. For years, I’ve been using our special ointments, oral medication, and supplements for the treatment of psoriasis.
Psoriasis is a non-contagious inflammatory skin disease associated with rapid skin cell multiplication. A variety of factors like hereditary, infection, environment, medications, stress, smoking, and genetics cause Psoriasis. The most common symptom of psoriasis is dry and itchy skin, formation of red patchy inflamed skin and stiff swollen joints.
It might sound strange to a dermatologist, but the actual cause of psoriasis is viruses. These two to three kinds of viruses attack the patient’s abnormal genes variants linked with the onset of psoriasis. Consequently, the immune system functions differently and causes inflammation. For this reason, immunosuppressant drugs such as methotrexate or cyclosporine help ease psoriasis significantly.
As the virus triggers psoriasis and alters the immune system, there must be a selection of holistic approaches for the effective treatment of psoriasis.
With more than 15 years of research, analysis, and completion, and treatment of more than 40,000 patients with varieties of skin diseases, we have created a unique formula for psoriasis treatment. With proven assurance, we have developed three special ointments – PS (1), MAS (1), and MA (1) to speed up the cure of psoriasis.
Not only this, but it also helps to cure varied forms of eczemas due to psoriasis, Pustulosis palmaris et plantaris (PPP), atopic dermatitis, nodular prurigo, and many other skin conditions. But, in cases like fungus or serious malignancy such as mycosis fungoides (cutaneous T-cell lymphoma), these ointments cannot cure eczema.
The psoriasis ointment list with its ingredients are as follows:
PS(1): difluprednate, clofibrate, jojoba oil, vegetable squalene, lanolin hydrous, macadamia nut oil, fermented extract of leaves of shell ginger, very fine powder of 5 kinds of mineral ores.
MAS(1): difluprednate and clobetasol propionate, licorice oil, moringa oil, macadamia nut oil, fermented extract of leaves of shell ginger, vitamin B1, B2, B12, alpha-lipoic acid, very fine powder of 5 kinds of mineral ores.
MA(1): triamcinolone acetonide and clobetasol propionate, moringa oil, macadamia nut oil, vitamin B1, B2, B12, alpha-lipoic acid, fermented extract of leaves of shell ginger, very fine powder of 5 kinds of mineral ores.
From the safety perspective, though these psoriasis ointments contain corticosteroid: a steroid hormone, the side effects are merely present. Unlike others, our ointments emit infrared rays from the fine powder of 5 stones. It leads to quick restoration of the skin.
PS (1) and MAS (1) are effective for the treatment of Psoriasis Vulgaris. Despite this, its efficacy seems to depend upon factors like race, climate, and food. For cases with fair and thin skin, MAS (1) is more potent. Hence, at first, I prescribe both PS (1) and MAS (1) to the patients and allow them to observe their efficacy for a week.
Here’s a case example: I recommend applying PS (1) on the lesion on the left side of the body and MAS (1) on the right side twice a day for a week to the patient. Later, the patient can identify the efficiency of ointment of psoriasis for his condition.
Also, for the treatment of Guttate psoriasis, MA (1) is recommended.
The first treatment step includes eradicating viruses that modulate the immune system using medications having insignificant side effects. The following two medicines have minimal side effects compared to immunosuppressant pills:
a. Erythromycin (Erythrocin® 200 mg)
Erythromycin is an antibiotic used in the treatment and prevention of several bacterial infections. Theoretically, antibiotics are only effective against bacteria, but realistically, Erythromycin seems to be effective against the virus as well. Therefore, I recommend this as good medicine for psoriasis.
As for myself, whenever I travel overseasthemin by long flights, I always take Erythromycin as prophylactic for two days before the flight. It works for the prevention of both bacterial and viral infections.
How to take: 4 tablets/day — Morning (2 tablets) and Evening (2 tablets). But the process of taking is unique. Please take the medication as follows:
As shown above, take the 4 tablets for four days and don’t take them for the following three days. For example, if you begin from Sunday, take 4 tablets/ day for Monday, Tuesday, Wednesday. And on Thursday, Friday, Saturday, you should discontinue the medication. You should again continue the same pattern by taking 4 tablets every day from the next Sunday to Wednesday and keeping a gap from Thursday to Saturday.
Repeat this cycle for 12 weeks (almost 3 months).
*If you are allergic to Macrolides, please don’t take this antibiotic.
b. Cepharanthine (Cepharanthin® 1 mg)
It is a naturally occurring alkaloid extracted from the plant Stephania cepharantha Hayata. In Japan, Cepharanthin® is a somewhat obscure medicine. As it is inexpensive, doctors are not interested in prescribing it (Doctors prefer costly drugs for business!!), and Cepharanthine is often underrated. Despite its value, it helps to cure diseases like Multiple Sclerosis, Ulcerative Colitis, and Hypothyroidism. Being able to modulate the immune system, Cepharanthin is beneficial in the cure of psoriasis.
Now, only one Japanese company manufactures Cepharanthin. I do hope the other companies continue the production of this notably potent psoriasis pill.
How to take: 3 to 4 tablets/day. Generally, you must continue it for 3 months.
It has few side effects in contrast to biologics such as Stelara or immunosuppressants such as MTX.
Q. How to take these two medicines for the treatment of psoriasis?
A. For the first month, use Cepharanthine only. In the following second and third months, take both Cepharanthine and Erythromycin. Finally, in the fourth month followed, take Erythromycin only. From the third month, you can also begin to take natural supplements. I especially prescribe this to undergo the best psoriasis treatment.
Shell Ginger Supplement (JIPANG Ginger®) 1400 mg ~ 2000 mg/day
1) Lipids
Psoriasis patients manifest significant lipid abnormalities. Though this might not apply to all cases, I have seen psoriasis patients with high blood cholesterol recover miraculously by cholesterol-lowering statin drugs. Dermatologists, however, disregard this fact as its efficacy is controversial.
If you search “statin psoriasis” you can find fascinating articles such as:(https://www.webmd.com/skin-problems-and-treatments/psoriasis/news/20100308/cholesterol-drugs-may-treat-psoriasis#1). There are opposing articles likewise, but I think it is worth trying. Although I am against statin drugs for lowering cholesterol, I still recommend them for psoriasis. Particularly Simvastatin, marketed under the trade name Zocor, shows effectiveness on psoriasis.
2) Biotin
Biotin (a kind of vitamin B-complex) falls among the essential vitamins that help cure psoriasis. This vitamin is required for fat metabolism and thus influences skin health.
Patients using antibiotics, intaking only α-lipoic acid, following dialysis, and consuming an excessive amount of egg white are likely to be deficient in this vitamin. Besides, people taking sleeping pills, antidepressants, and antiepileptic drugs for a longer duration also lack biotin. As some species of lactic acid bacteria feed on biotin, you must limit intake of yogurt cautiously.
Dosage of biotin for psoriasis: 10 mg to 15 mg/day. Please do not mistake the unit. It is 10 mg to 15 mg (10,000 mcg to 15,000 mcg), not 10 mcg to 15 mcg (10 μg to 15 μg). Many biotin supplements contain 5000 mcg of biotin per capsule, in such cases, 2-3 capsules per day are recommended.
You should continue biotin supplements for at least six months. You must discontinue smoking, as biotin does not work efficiently with smoking.
3) Omega 3 Unsaturated Fatty Acid: 3000 mg to 4000 mg /day
Omega-3-fatty acids are one of the best supplements for psoriasis as it plays a vital role in reducing inflammation. Harp Seal Oil is very stable, contains EPA, DHA, and DPA, and is the best source of omega-3 fatty acids. These essential fatty acids circulate in human blood and maintain soft, plaque-free arterial walls. They also reduce inflammation and produce a healing effect on the cells of the skin. Furthermore, from these unsaturated fatty acids, beneficial eicosanoids are metabolized, which facilitates the cure of psoriasis.
But, if you love such a cute animal as Harp Seal and would not like to sacrifice their lives, you can choose Sacha Inchi Oil. And if you would like to economize, Flaxseed Oil can be a good substitute for omega-3 fatty acids.
4) Inositol (750 mg to 1000 mg /day)
Inositol is a vitamin-like substance synthesized in small quantities in our bodies. Phytate, naturally present in cereals and grains, acts as a precursor of inositol. Phytin, phytic acid, and inositol have different functions, such as maintaining cholesterol levels and promoting skin health. In some cases, psoriasis patients suffer from hyperlipidemia. Hence, rectifying it reduces the severity of psoriasis and is a potent supplement for psoriasis.
5) Zinc (40 mg/day Zinc Monomethionate or Zinc Picolinate)
Zinc regenerates collagen and maintains skin composition, being a vital mineral supplement for psoriasis. It is readily available online or at any vitamin shop and is reasonably priced. However, like copper, if you take zinc supplements at a higher dose for a long time, side effects are anticipated. Therefore, a doctor’s consultation is necessary. Zinc supplement is not advisable for hepatitis patients or those who are the carrier of the hepatitis virus.
6) Copper (4 mg to 6 mg/day)
Viral infections lead to the onset of psoriasis. Although mainstream medicines disagree with this viewpoint, copper suppresses the growth of the virus, making it another effective psoriasis supplement. Besides, they are affordable and available easily.
You should not take copper supplements continuously for a longer duration. You can take it for no longer than 3 months. After a gap of a month, you can again take it for 3 months. You can continue the cycle in a similar pattern.
7) Selenium: 200 mcg/day
Another effective mineral supplement for psoriasis is selenium. It synthesizes the glutathione peroxidase enzyme. This enzyme protects the cell from oxidative damage by neutralizing free radicals.
Selenium forms selenocysteine, an enzyme required in the activation of the thyroid hormone. It helps to convert tetraiodothyronine (T4) to triiodothyronine (T3). The deficiency of active thyroid hormone T3 adversely affects psoriasis.
8) Magnesium (200 mg/day Magnesium Glycinate is recommended)
About 325 kinds of enzymes are directly dependent on magnesium for functioning. If our body lacks adequate magnesium, the physiological function and metabolism will paralyze. It has a detoxification effect on toxic substances, which helps expel heavy metals and their complexes outside the body quickly.
The nicotine of cigarettes or a large amount of alcohol (the moderate amount is not a problem) can drain magnesium. Also, the intake of magnesium can impair the action of hypothyroidism drugs like levothyroxine. A common side effect of intake of magnesium supplements is passing of soft stool and onset of diarrhea. Hence, take the supplement under supervision.
9) Vitamin K2 as Menatetrenone
Tumor necrosis factor α (TNFα) antagonists play an indispensable role in curing psoriasis. Due to this reason, biologics such as infliximab (Remicade®), etanercept (Enbrel®), and adalimumab (Humira®) are in use for treatment.
Yet, the approval of these biologics is contradictory in patients with diseases like chronic leg ulcers, chest infections, congestive cardiac failure, and malignancy. The reason behind this is their immunosuppressive nature and high cost.
Vitamin K2 is a bonus alternative as it can inhibit the production of TNFα, is safe and economical, making it the best choice for the treatment of psoriasis.
I’ve been asking by many patients while treating psoriasis. So i write here frequently asked question by patients.
With the use of ointment, about more than 90% of the lesions disappeared. It is used for symptomatic treatment and cannot cure internal problems, but it improves social life significantly. Without the intake of medicines (Cepharanthine/ Erythrocin), and supplements (Shell Ginger/ other), the symptom might reappear anytime soon.
With Cepharanthine, Erythrocin, Shell Ginger, and other supplements, you can be free from psoriasis for a year or more. After that, we cannot predict the duration it takes to be free from psoriasis as it depends upon numerous factors, particularly mental stress. Proper diets, low-stress levels, and exercise reduces the recurrence rate by less than 30%.
PS(1) 50 g: ¥4200
PS(1) 100 g: ¥7140
MAS (1) 50 g: ¥4200
MAS (1) 100 g: ¥7140
MA(1) 50 g: ¥4200
Erythrocin (64 tablets for a month): ¥3520
Cepharanthin (120 tablets for a month): ¥3960
Oil Paper (100 sheets): ¥1600
Bio-Three (60 packs for a month): ¥1380
Minimum Shipping Cost: ¥1400 (to Asia), ¥2000 (North America, Australia, New Zealand), ¥2200 (Europe), ¥2400 (South America, Africa)
Consultation: Free, if on the Internet.
One US dollar ($) is 105 ～115 Japanese yens(¥). It depends on the exchange rate of the day. Therefore, for exmaple, PS(1) 50g costs $36.5 ～$40.
You don’t need to take them forever!
These natural supplements for psoriasis are effective for “Maintenance Therapy” of psoriasis. Moreover, it aids in preventing cancer, cardiovascular diseases, cerebrovascular diseases, rheumatoid arthritis, depression, etc.
I’ve been taking these supplements for more than ten years to maintain my general health. Hence, I recommend them for a longer duration.
I’ve not witnessed any adverse side effects caused by these two medicines. Except one of my patients complained of abdominal bloating after taking Cepharanthine. I advised him to discontinue the medication. If any symptom appears after taking medicine, please consult your doctor.
Erythromycin (Erythrocin®)
Contraindications: If you are taking the following drugs, please don’t take Erythromycin.
Ergotamine tartrate / anhydrous caffeine / isopropylantipyrine <Clamine> / dihydroergotamine mesylate <Dihidelgot> / Pimozide <Aurapp> / Asunaprevir <Sunbepura>
Attention: If you are on one of the following medications, please consult your doctor before using Erythromycin along with the medicines.
Antiarrhythmic drug/Warfarin potassium/Theophylline/Aminophylline hydrate/Cyclosporine/Crolimus hydrate/Digoxin (Lanoxin)/Felodipine (Plendil,Renedil)/Valproate (VPA) (to treat epilepsy)/Midazolam/Carbamazepine(Tegretol)/Colchicine/Simvastatin/Atorvastatin(Lipitor)/Pitavastatin/Blonanserin/Ebastine/Edoxaban/Zafirlukast/Ritonavir/Cimetidine(Tagamet)/any anti-cancer drugs.
Caution: If you are on Calcium Channel Blocker (such as Amlodipine) for lowering your blood pressure, please avoid taking Erythromycin. It is because the combination of Amlodipine and Erythromycin may lead to hypotension.
Azithromycin is a macrolide antibiotic and is safe with Amlodipine. Also, macrolides are very important in the treatment of psoriasis. Thus, if you are currently under the medication of CCB, Azithromycin is the most suitable choice. But its potency is less than that of Erythromycin.
Patients often ask, “If I have been taking Erythrocin, an antibiotic for three months, are the side effects unsafe?”. The answer is that it is generally not dangerous unless you have severe disease. For example, Erythrocin is prescribed in cases like COPD (Chronic Obstructive Pulmonary Disease) continuously for one year. If we compare the side effects, the side effects of erythromycin are pretty minimal as compared to steroid pill/immunosuppressants such as Methotrexate, biologics such as ustekinumab (Stelara).
Even so, if any symptoms appear with Erythrocin (or Azithromycin), you should immediately stop it and consult your doctor.
Cepharanthine (Cepharanthin®)
There are no contraindications observed with Cepharanthine yet.
It depends upon the size and number of plaques or eczema. So, it is not possible to say how much you need it. But for mild cases, usually, 50 g/month is enough. After the lesion disappeared, you don’t need it till relapse.
There are certain foods to avoid with psoriasis, but the one-word answer for this question is becoming a vegetarian!! I can understand that for many, this diet is hard to adopt. Still and all, try to avoid animal products such as meat, milk and cheese, and whey as much as possible.
Looking through history, about 150 years ago, when western civilization was unknown in the east, people did not consume meat as Buddhism prohibited meat-eating and the killing of animals. Psoriasis was foreign in the east at that period. After the influence of Western culture, psoriasis began to emerge in Japan but, it is not as prevalent as in the US and Europe. The prevalence of psoriasis in Japan is 2 to 3 of 1000 people and 2 to 3 out of 100 people in the US. The prevalence rate is ten times higher in the United States. It is not due to genetics but rather because of diets.
Since the diet plays a vital role in curing several ailments, it is necessary to find out what kind of food triggers psoriasis in your case. As psoriasis rarely occurs in strict vegetarians., the best and cheap treatment of psoriasis is to become a vegetarian.
Adopting a vegetarian diet can reduce the symptoms in three years. Some patients try a low carbohydrate diet. But a low carbohydrate diet contains excess lipids and protein, which worsen psoriasis.
Q. If a high carbohydrate diet is unhealthy for psoriasis, why do the Americans suffer more than the Japanese?
A. Rice, a rich source of carbohydrates, is the staple food of Japan. Undoubtedly, an excess amount of carbohydrates is harmful to psoriasis, but excess lipid is even worse. By seeking a proper diagnosis of your condition, you can find the best psoriasis treatment.
* Periodic Fasting: You can practice it even once in a half year. It can give a good rest to your intestine, helps for detoxification, and improve the condition of psoriasis soundly. You can either visit a clinic offering a fasting course or can easily find it on the internet. Please do not practice it without consultation.
Iron
There is an association between the metabolism of iron and psoriasis. When anemic patients with psoriasis take iron supplements, their condition deteriorates, as red blood cells contains iron. You must stop taking unnecessary iron supplements in such cases. It also explains why the symptoms ease when a psoriasis patient gets phlebotomy (bloodletting).
Please don’t take excess vitamin C supplements, as it stimulates the absorption of iron.
Probiotics
Probiotics improve digestion by increasing good bacterias and crowding out harmful bacterias in our gut.
Intestines are the largest immune system organ in the human body. Here, many hair-like villi occupy the small intestine with Payer’s patches. These patches have a crucial role in monitoring the immune system. Besides, our gut is known as the second brain due to its connection with the brain. Together, the brain and the intestine control our emotions, stress, cravings, and sleep.
It explains the importance of maintaining the intestinal environment to maintain a healthy state. The severe symptoms of psoriasis, caused by extreme stress and anxiety, can only be resolved by ensuring the good health and functioning of the intestine.
We use a preparation called Bio-Three. It is the trade name of a probiotic product, which contains three active strains of host-friendly bacteria, E.faecalis T-110, C.butyricum TO-A, and B.mesentericus TO-A. Research has shown that the combination of these three bacteria provides optimal synergistic effects.
For more details, please open http://www.bio-three.com/. It is the website of the manufacturer, but it might not be available in your country. If so, please find any suitable probiotics on the internet. You may have to try three or four different probiotics until you find the best one that suits your intestine.
* Also, try to eat one apple a day. The pectin of the apple has dietary fiber and helps in maintaining a healthy environment in the intestine.
* Ayurvedic medicine recommends cleaning our tongue because it helps to improve your gut flora. Please clean your tongue with a tongue cleaner twice a day. You can find a tongue cleaner easily on the internet or in a general store.
Detoxification
Detoxification is necessary to eliminate substances like heavy metals, toxic chemicals, artificial food additives, fragments of medicines, viruses, bacteria, etc., that cause psoriasis.
It is a great traditional system of medicine, including classical Chinese, Ayurvedic, and Tibetan medicine. According to the conventional method, toxins collected in the body undergo detoxification before prescribing therapeutic medication. In contrast, the modern practice provides prescriptions to patients with no prior detoxification.
One of the best ways of detoxification is taking a sauna (thermal bath), especially one using far-infrared rays. In this method, toxic substances excrete through sweat. Yet, one should not take saunas more than three times a week.
Bloodletting (phlebotomy) is also an effective way of detoxification. A warning, which may seem obvious, but is critical anyway, is never to undertake phlebotomy on your own. Only trust experienced health professionals to carry out the process. Please have a look at this: https://en.drmakise.com/shaketsu/.
* Drink plenty of water: You should drink at least 1- 2 liters of water per day, preferably in the morning. Water detoxifies many toxic matters that intensify psoriasis. But if you have a kidney problem, please consult your doctor about the safe level of water intake.
Ultraviolet (UV) Light
Solar UV light stimulates the production of vitamin D, which is necessary for the cure of psoriasis. Vitamin D minimizes the scaling of the skin by decreasing the overproduction of skin cells. Still, sunbathing near the window is not an effective method. The best way is to stay under the natural rays of the sun. It may take several weeks to see an improvement in your psoriatic lesions. Some people even travel to a tropical zone, an approach worth trying.
UV blood irradiation therapy also uses UV light, today commonly known as photoluminescence. It is a modern technique to treat diseases, including psoriasis, and is safe from adverse side effects.
Go to bed early
Sleep is one of the overlooked aspects of maintaining good health. You should go to bed at least by 11 pm, and if you go to bed later than midnight, your psoriasis can never get cured.
The growth hormone secretes from the pituitary gland between 11 pm to 3 am (3 hours after you fall asleep). Late sleeping habits can hinder the release of the growth hormone and impact skin damage. You know well that the human growth hormone is flaunted very much as an anti-aging supplement. Some anti-aging clinics offer injections of growth hormones, but the best way is to go to bed earlier. Note that the growth hormone gets secreted even if you are 80 years old or more.
When the blood glucose level is high, the pituitary gland cannot secret growth hormones sufficiently. Thus, do not go to bed at least 2 hours after dinner.
Caution
If you feel joint pain, stiffness, or swelling along with the skin symptoms of psoriasis, please consult your doctor first. You might be suffering from Psoriatic Arthritis, and you may have to take immunosuppressants such as Methotrexate immediately to avoid deformation of joints.
Concluding remarks
I have treated many people in Japan with this approach for the treatment of psoriasis. Even though psoriasis is a chronic skin disease, its symptoms can be alleviated and even cured by proper care and supervision. Using ointments for psoriasis is one of the best ways to relieve the symptoms of psoriasis. The origin of this disease is due to viruses that infect skin cells and affects the immune system.
Hence, the inactivation of viruses with oral medications, use of ointments, and maintenance therapy of minerals and vitamins can treat psoriasis efficiently and effectively. If you practice proper care, guidance, medicines, and diet, you can even prevent relapse of this disease.