Natural Supplements that prevent BPH

First of all, it is very important to distinguish BPH from prostate cancer. Be sure to go to an urologist for examination. You cannot lose your life due to BPH, but if it is cancer, it can be life-threatening when it spreads to other organs.

Usually the treatment begins with drug therapy. The following three are mainstream drugs.

α1 blocker
5-α-reductase inhibitor
PDE5 inhibitor

If they don’t work, surgery is performed.

Transurethral prostatectomy (TUR-P: Transurethral Resection of Prostate)
Holmium Laser Enucleation of Prostate (HoLEP)
Photoselective Vaporization of Prostate (PVP)

Of the above, holmium laser prostate enucleation seems to be the most common. However, you should consult with your doctor to determine the most appropriate operation for you.

Although surgery for prostatic hypertrophy has made great progress and the incidence of postoperative ED (erectile dysfunction) or urinary incontinence is decreasing very much. But it cannot be denied that ED or urinary incontinence occurs as sequelae with a small probability. In addition, retrograde ejaculation (a state in which sperm is ejaculated into the bladder) may occur, which can cause infertility. Therefore, those who plan to have children are advised to avoid surgery if possible or postpone the surgery.

Natural supplements that prevent BPH are almost the same as the supplements against prostate cancer. So, please read the page of “Prostate Cancer”. But here I add 3 supplements that improve BPH. Whenever you take them, first of all please talk to your doctor.

Pumpkin seed oil

This also has the inhibitory effect of 5-α-reductase, like saw palmetto extract, and prevents prostate enlargement. It also has an aromatase inhibitory effect. Aromatase metabolizes testosterone to an estrogen called 17-β-Estradiol (E2). It has the strongest effect of estrogen, thickening and enlarging prostate tissue.
Pumpkin seed oil also increases the stock of urine by relaxing the bladder smooth muscle via the adenosine A1 receptor, which is related to the bladder urination reflex. As a result, pumpkin seed oil reduces urinary frequency and urinary urgency.

There are many studies in Europe, especially Italy and Germany.
The role of Cucurbita pepo in the management of patients affected by lower urinary tract symptoms due to benign prostatic hyperplasia: A narrative review
Also in Africa. The below is from Nigeria.
Inhibition of the experimental induction of benign prostatic hyperplasia: a possible role for fluted pumpkin (Telfairia occidentalis Hook f.) seeds.

Nettle (Urtica dioica)

The roots of this plant are used to prevent the prostate problems (the leaves are for allergic problems). Testosterone decreases with age, and estrogen increases in men. This is the effect of an enzyme called aromatase. Estrogens thicken the prostate tissue and enlarge it.
Lignans contained in nettle prevent binding of androgens to SHBG (sex hormone binding globulin) in benign prostatic hyperplasia

The histological and histometrical effects of Urtica dioica extract on rat’s prostate hyperplasia
And nettle prevents the conversion of testosterone into dihydrotestosterone. This effect is the same as saw palmetto.
Ameliorative effects of stinging nettle (Urtica dioica) on testosterone-induced prostatic hyperplasia in rats.


Melatonin is a hormone secreted from an organ called the pineal gland located in the uppermost part of the upper wall of the third ventricle, which is located almost in the middle of the brain (recent research has shown that it is produced in every organ of the human body. Especially in the intestines, it is produced 500 times more than in the pineal gland). 

Melatonin has once become a boom as a rejuvenating hormone. In addition, it is often taken as a jet lag countermeasure or as a sleeping pill, but recently it has also attracted attention as an antioxidant and anti-inflammatory supplement.
Furthermore, it is also closely related to the function of the bladder and prostate. Melatonin reduces nocturia by increasing bladder capacity in a dose-dependent manner and reduces nighttime urine production.
Melatonin peaked at the age of 6-7 years and will decrease by 2% every year with age. Therefore, in the mid-thirties, the production volume is almost half.
There are several types of melatonin — 1 tablet contains 0.75mg, 1mg, 2.5mg, 3mg, 5mg, 10mg, 20mg. There are also liquid types and combinations with other supplements. I usually prescribe 1 mg of melatonin per tablet, because it can be easily increased or decreased according to the symptoms. The amount you can sleep without worrying about your urine until morning varies from person to person. First, take 1 mg before going to bed. If you feel that is not enough, increase one tablet at a time. As the prostate enlargement itself shrinks, melatonin is no longer necessary. However, as a rejuvenating hormone, you may take 0.5 to 1 mg every night. For 0.5 mg, remove 1 mg melatonin capsule, take out the powder and take half of it.
“N-acetyl-5-methoxytryptamine” is the scientific name of melatonin. If you find this long name in your supplement, it is exactly the same substance as melatonin. No new substance. Some products claim as if “N-acetyl-5-methoxytryptamine” was a new substance discovered by scientists. But please don’t be fooled by their claim. That’s simply melatonin which you can find at any vitamin shops.

*Bladder muscle training

Whenever you urinate in the toilet, please be patient for 3-5 seconds. This results in “muscle training” of the bladder, leading to improvement of frequent urination, increased urgency. A slight stack of seconds will work.

** Be careful with aphrodisiacs

If you take for a long time a non-pharmaceutical aphrodisiacs such as Horny Goat Weed, Catuaba,Yohimbe, Tribulus Terrestris, Muira Puama, Tongkat Ali, etc., there is a risk of prostatic hypertrophy. These aphrodisiacs should be taken for a short time, if necessary.

*** Improve general health

Obesity, diabetes, metabolic syndrome and arteriosclerosis exacerbate prostate enlargement. Also, sitting life is not good for prostate.

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