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Essential Supplements 9-11

Therapeutic Prescriptions by Vitaminx & Minerals

This is information obtained from Dr. Makise's having cured atopic dermatitis of 40,000 people or more in total and the latest and highest atopic dermatitis treatment. But this is provided for information only. No action should be taken based solely on the contents of this website; instead, readers should consult appropriate health professionals on any matter relating their health. Readers who fail to consult with appropriate health authorities assume the risk of any injuries. Dr. Makise is not responsible for errors or omissions.
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9. Biotin(Vitamin H):5mg-10mg/per day. Please note this is not microgram, but mg.

This Vitamin is named after Haut, German for skin, after a German researcher discovered that this vitamin prevented skin inflammations in mice. This is also a type of soluble Vitamin B.
Biotin’s main purpose is to aid the production of prostaglandin E3, a type of benign eicosanoid and EPA(eicosapentaenoic acid), from α-linolenic acid. In other words, it prevents skin inflammations. It also eliminates a type of amino acid, histidine, from the body.
When histidine reacts with decarboxylase, histamine, which causes itchiness, gets produced. In addition, biotin strengthens the capillaries under the skin’s basal layer, and aids to production of new skin. This also helps curing hangnails. Veterinarians have been using this to strengthen the hoofs of horses. Although different from AD, this also helps palmoplanter pustulosis (If you have this, use 9 mg to 12mg per day).

Infants do not have well developed intestines, and as a result they don’t absorb or produce biotin as much, which can lead to biotin deficiency. Formula-fed babies, in particular, tend to develop deficiencies since the powder milk in Japan contains less biotin compared to those in the US. There are even some doctors who contend that the reason why Japanese babies are so susceptible to AD is because there is not enough biotin in their milk. Biotin is also effective in healing napkin rashes.

Also, you must take in manganese to make biotin function effectively. You need 3 mg to 4 mg per day, but this is equal to what you take in from your everyday diet. However, if you take in too much calcium, it will get in the way of manganese absorption. Those who need to take calcium supplements should be careful. Also, manganese is sometimes called “Love’s mineral” or “Love’s salt”, and is a necessary mineral for nursing women. As a result, if a nursing woman or a weaning child is developing AD, it is recommended that she take biotin. Also, manganese is necessary for the production of ceramide, as mentioned in section 6. I wrote that a cup of pineapple juice contains 3 mg of manganese, so you should drink it every day.

Manganese is also essential for the production of thyroid hormones. Recently, there have been reports of hidden hypothyroidism in young women. These patients don’t show any irregularities in their blood tests but have symptoms such as constipation, body temperatures below 36 degrees, light-headedness, listlessness, a slow pulse, and pudginess (but not obesity). Irregularities in the thyroid gland, whether it be underaction or overaction, will worsen AD.

Biotin levels tend to be low for the people listed as follows. These people include those who receive dialysis, take antibiotics, people who take only α-lipoic acid, eat lots of egg whites(there are some body builders who make protein shakes out of egg whites. They take out the yolk to avoid unnecessary cholesterol. If you drink those shakes on a daily basis, as mentioned in the section about eggs, avidin,
a protein found in egg whites, will combine with biotin and hinder its absorption), take antidepressants, sleeping pills or antiepileptics over a long period. This is an important but highly unnoticed fact. Many AD patients have mental issues and take these pills for many years. They do not notice that these pills interfere with the absorption and ingestion of biotin into cells and worsen AD symptoms. Be cautious of psychoactive drugs that are structured like carbamide and ureide. The explanation for this gets rather technical, so ask you doctor about this.

Please take in biotin for at least 3 months (if you have palmoplanter pustulosis, use it for around 6 months). If you don’t see any change in your symptoms, there was no biotin deficiency. When you take biotin, also supplement α-lipoic acid and manganese from one cup of pineapple juice, and avoid the following; eating yogurt with lots of bifidobacteria, egg whites, antipsychotic drugs and stop smoking.
Otherwise, biotin will not work effectively. Also, biotin complements Miyairi bacteria, so it is recommended that you take both of these at the same time.

10. α-lipoic acid: 300mg/Day

α-lipoic acid has started to garner attention, just like CoQ10, due to the increased demand for weight loss and anti-aging supplements.
These are synthesized in the body at small amounts, so it does not count as a vitamin. Also called thioctic acid, α-lipoic has been used as a therapeutic agent to help drug addicts. Even to this day doctors are familiar with the word thioctic acid. In “The Alpha Lipoic Acid Breakthrough”, Bart Berkson, Ph.D, writes about how α-lipoic acid saved the lives of 4 patients who ate poisonous mushrooms in the late 70’s. The mushrooms nearly destroyed the liver, but α-lipoic acid saved the lives of these 4 people.
After further research, it was discovered that α-lipoic acid has a strong antioxidant ability and is soluble in lipids and water. It is now used for detoxification and treating diabetes, cancer, and cardiovascular problems. Since it is also effective in protecting the skin from active oxygen, as I have written before, it is used in MA ointments and relapse prevention ointments. Also, since it strengthens the liver’s functions, it has strong detoxification capabilities, and AD patients with severe symptoms sometimes get α-lipoic acid injections at my clinic.In addition, if you’re taking omega 3 unsaturated fatty acids from flax seed (or oil) or chia, it is recommended that you take α-lipoic acid to prevent the oxidation of the unsaturated fatty acids.

11. Selenium:50µg-150µg/Day

This trance mineral has finally started to receive attention, and is an essential antioxidation supplement that you must take. Selenium is needed to make glutathione peroxidase, an enzyme with powerful antioxidant effects. This also works hand in hand with Vitamin E. The importance of this mineral has finally been recognized, and is put in mineral supplements, such as zinc, manganese, molybdenum, and iodine, that can be bought not only at drug stores but at convenience stores as well. However, make sure that you can get at least 50µg X of selenium per day from your supplement.


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