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More on the real causes of Atopic Dermatitis (B) Overabundance of Th2 cells relative to Th1 Cells

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This is information obtained from Dr. Makise's having cured atopic dermatitis of 40,000 people or more in total and the latest and highest atopic dermatitis treatment. But this is provided for information only. No action should be taken based solely on the contents of this website; instead, readers should consult appropriate health professionals on any matter relating their health. Readers who fail to consult with appropriate health authorities assume the risk of any injuries. Dr. Makise is not responsible for errors or omissions.
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(Ⅶ) More on the real causes of Atopic Dermatitis

(B) Overabundance of Th2 cells relative to Th1 Cells

1. Th1 and Th2

Th1 cells and Th2 cells are lymph cells related to the immune system. If you look at the diagram below, you can see what kind of cells Th1 cells and Th2 cells are. These cells are a differentiation of lymph cells, a type of white blood cell.

T1 and T2

Th1 cells aid killer T cells, activate macrophage, and attack and destroy bacteria and viruses and prevent infections. They also make B-cells produce IgG antibodies and cause type 2 and 3 allergies (type 2 allergies include hemolytic anemia and myasthenia gravis, and type 3 allergies include serum sickness and glomerulone phritis, all of which will not be dealt in detail).

Th2 cells make B-cells produce IgE antibodies, which attaches to allergens and stimulate the mast cells. These mast cells release histamines and leukotriene, which causes allergy symptoms. As a result, when the amount of Th2 cells increases, the symptoms of type 1 allergies (which include hay fever, bronchial asthma, food allergies, and AD) worsen.

Th1 cells and Th2 cells release different kinds of cytokine, so that they maintain a balance in the immune system. However, allergy patients produce more Th2 than Th1 (the normal ratio between Th1 and Th2 is 8 to 12).


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