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This is information obtained from Dr. Makise's having successfully addressed psoriasis using only safe alternative natural medicines. This is provided for informational purposes only. No action should be taken based solely on the contents of this website; instead, readers should consult appropriate health professionals on any matter relating to their health. Readers who do not consult appropriate health authorities assume the risk of any injuries they may sustain as a result of following these recommendations. Dr. Makise is not responsible for an associated errors or omissions.
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Natural and Safe Treatments for Psoriasis

Effective and Unique Treatment For Psoriasis From Japan

I am not a dermatologist, but a general physician. I see psoriasis as an "inside out disease" which is a different view from ordinary dermatologist's.

  • Lipids are connected with psoriasis. Being a physician, I have seen hyperlipidemia ( high cholesterol ) patients with psoriasis are cured miraculously by cholesterol lowering drugs (statin drugs). This is not the case for many, but a few patients are cured by only statin drugs.
    But dermatologists ignore this fact or dermatologists don't know this fact. Please search by Google [ statin drugs psoriasis]. You will find lots of articles and you can read controversial opinions.

  • The main cause of psoriasis is two or three kinds of viruses, we think. Those viruses attack the patient's abnormal variants of genes connected with the onset of psoriasis. And the immune system gets out of order. Therefore immunosuppressant drugs such as Cyclosporine alleviate psoriasis very much.We don't know yet the viruses, but we infer the viruses are not so special viruses, Rather, we may be familiar with them. But we still don't know how those viruses can trigger the onset of psoriasis. But in any cases, they trigger psoriasis when the patients are under excess physiological or mental stress. Especially mental stress aggravates psoriasis, as is often the case with any diseases.

  • Iron metabolism is connected with psoriasis. --- When anemia patients with psoriasis take iron supplements, their psoriasis worsens. When psoriasis patients get phlebotomy ( blood letting) the symptoms get alleviated. Blood --- red blood contains iron. Please refrain from taking unnecessary iron supplement, if you can do without it. And please don't take too much vitamin C supplement that accelerates the absorption of iron at the intestine.

For A) --- Taleju Oil, Flaxseed Oil, and Gamma Oryzanol are effective. Taleju Oil is a blend of different natural essential oils obtained from different herbal plants from Himalayan region of Nepal and a plant from Okinawa island. Mint oil, eucalyptus oil, camphor oil, wintergreen oil, xanthoxylum oil, lemongrass oil, cinnamon leaf oil, and shell ginger oil. Recommended use: Put 3 or 4 drops of oil in 6-8 ounces of hot water, and please inhale the oil's evaporated steam. Open http://nepalmedicine.weebly.com/.

Flaxseed Oil : 3000 mg/day
Gamma Oryzanol : 100 mg - 200 mg

And if possible, please add inositol that promotes the healthy metabolism of lipid. 1000 mg/day

For B) --- Copper is effective. Copper kills viruses. Recommended dosage is 8 mg/day. Taleju Oil is also effective against ailments caused by viruses.

Biotin is very effective for psoriasis. Because it reduces mental stress and also improves the skin structure. Take large dose of Biotin -- 15,000 ~ 30,000 mcg/day.

And in order to make these supplements work synergistically Shell Ginger Supplement and Magnesium are important. The leaves of Shell Ginger (Alpinia zerumbet) from Okinawa island contain many kinds of polyphenols such as kaempferol, ferulic acid, chlorogenic acid, quercetin, etc. I have been prescribing this supplement almost for all ailments since 7 years ago to enhance the synergy of various supplements and find excellent effects. For centuries leaves of Shell Ginger has been used in Okinawa, Japan, whose population is frequently cited as "the healthiest on earth". For more information, please open: Makise Lifeup Laboratory

Shell Ginger Supplement : 1400 mg ~ 2000 mg/day

Magnesium: 200 mg/day. Magnesium Glycinate is recommended.

Zinc : 40 mg/day. Zinc Monomethionate or Zinc Picolinate. Zinc is very important mineral for collagen synthesis.
But if you once suffered from hepatitis or you are carrier of hepatitis virus, please don't take zinc supplement.
And don't take zinc continuously for a long time. If you take it for two months, please don't take it for the next one month.

If you suffer from serious psoriatic eczema and want to alleviate soon, you have 2 choices.

  • Apply our ointment
  • Take Cyclosporine

Although they work quickly, both are just symptomatic treatments. You should not rely on these treatments for a long time. But they improve your social life quickly.

Biologics such as Stelara, Enbrel, Humira, Remicade, etc: I don't recommend, because very expensive and sometimes serious side effects occur. Only for very serious cases of rheumatoid arthritis, biologics may be necessary. I'v never prescribed biologics for psoriasis.

Our ointments; PS(1), MAS(1), MA(1)

PS(1)-- For large plaque and/or for those patients who suffer from psoriasis more than 5 years.
MAS(1)-- For small psoriatic eczema and/or for those patients who suffer less than 5 years.
MA(1)--- For guttate psoriasis.

Although these 3 ointments contain steroidal hormone, the side effects are really minimal compared to ordinary steroidal ointments.

PS(1)The ingredients are difluprednate (a corticosteroid), jojoba oil, vegetable squalene, lanolin hydrous, macadamia nut oil, fermented extract of leaves of shell ginger, fine powder of 5 stones that emit infrared rays.
MAS(1)It contains 2 corticosteroids -- difluprednate and clobetasol propionate, licorice oil, moringa oil, macadamia nut oil, fermented extract of leaves of shell ginger, vitamin B1, B2, B12, alpha lipoic acid, fine powder of 5 stones that emit infrared rays.
MA(1)2 corticosteroids -- triamcinolone acetonide and clobetasol propionate, moringa oil, macadamia nut oil, vitamin B1, B2, B12, alpha lipoic acid, fermented extract of leaves of shell ginger, fine powder of 5 stones that emit infrared rays.

So, summary is :

  • Shell Ginger Supplement ( JIPANG Ginger®)
  • Taleju Oil
  • Flaxseed Oil
  • Gamma Oryzanol
  • Inositol
  • Biotin
  • Magnesium Glycinate
  • Copper
  • Zinc
  • Ointment: PS(1) or MAS(1) or MA(1)
  • Cyclosporine

You can find Flaxseed Oil, Gamma Oryzanol, Inositol, Biotin, Magnesium, Copper, Zinc at any vitamin shops or by the Internet in your country, though probably Shell Ginger Supplement, Taleju Oil are not possible. And our ointments are sold only at my clinic in Japan. So, if you are interested in them, we can send you from Japan. Please inquire and contact us : https://www.drmakise.com/en/mail/

* Flaxseed oil : Omega 3 unsaturated fatty acid is very important for health. For the skin, please don't use Omega 3 unsaturated fatty acid from fish oil. Please use plant origin such as flaxseed oil. Or "Sacha Inchi Oil", though it is more expensive than flaxseed oil. Or we recommend our product " Omega Plus Revolution" that is composed of Flaxseed Oil, Camellia Seed Oil, and Pine Needle Oil. Please don't apply the oil on the skin. But drink it.

* Cyclosporine: Of course, please consult with your doctor. Use it very carefully. Usually I recommend ointments more than Cyclosporine , because the side effects of Cyclosporine are far more serious than those of ointments. When the flare-up is very serious and you need to reduce it down quickly for your social life, please take it with much caution.

And the following 4 can alleviate psoriasis very much.

Becoming A VegetarianPrevalence of psoriasis in Japan is 2 to 3 of 100 dermatology patients and 2 to 3 of 1000 ordinary people. The incidence is higher in the US, where it occurs in 2 to 3 of 100 people. It means 10 times more in the US. This disparity in prevalence between Japan and the United States is not based on genetics, but rather on diet. Up to 150 years ago, before Western civilization culturally impacted the East, Buddhism prohibited meat eating as well as killing animals. Psoriasis was unknown in Japan at that time. After the Western influence was introduced, gradually psoriasis emerged among them, although it is not nearly as prevalent as in the United States and Europe. Psoriasis is, however, relatively rampant in China, because the Chinese eat a fair amount of pork. One can justify blaming meat for the condition as in the US and Europe, psoriasis rarely occurs in strict vegetarians. The best and definitely most economical treatment of psoriasis is to become a vegetarian. If one refrains from eating animal meat at least for three years, doesn't drink cow's milk or eat cheese, psoriatic symptoms will greatly improve naturally without any treatment in approximately three years.

Some patients try " a low carbohydrate diet". It does help some patients, as far as you can limit too much lipid and protein. But if you are on a low carbohydrate diet, you tend to take too much lipid and protein that may worsen psoriasis. As I wrote, lipids are connected with psoriasis very much.
And if " a high carbohydrate diet" is bad for psoriasis, why do the Japanese suffer less than the Americans? Rice is the staple of Japan and the rice is typical carbohydrate. Of course, too much carbohydrate is bad, but especially too much lipid is really bad for psoriasis. That's why some hyperlipidemia ( high cholesterol ) patients with psoriasis are cured miraculously by cholesterol lowering drugs (statin drugs).


It is important not to forget that the intestine is the body's largest immune system organ. Many hair-like villi occupy the small intestine, with Peyer's patches and their patchwork-like structure between them. Peyer's patches are a collection of lymph follicles, major players in controlling the immune system. Also, the epithelium in the small intestine contains 1 lymphocyte for every 5 to 6 epithelial cells, and accounts for 60% of all immune system cells in the human body. In addition, a Japanese researcher recently discovered lymphoid tissues containing undifferentiated lymphocytes called cryopatches. These cryopatches house lymphoid precursor cells that become intraepithelial T lymphoctyes with their central role in cell-mediated immunity. It is easy to see how important it is to maintain intestinal health to effectively treat skin disorders such as psoriasis and atopic dermatitis. By virtue of its massive surface area, the intestines are linked to the brain, so much so, that the intestines are called the second brain. They are typically 6 to 7 meters (~19 to 23 feet) long in adults. The intestines are composed of almost 100 million nerve cells, constituting 50% of all nerve cells in the body aside from those in the brain. Together, the brain and intestines control emotions, stress, and sleep. Consequently, the severe symptoms of psoriasis that are caused by extreme stress and anxiety can only resolve by ensuring that the intestines are patent and functioning well. Although the constraints of space will not allow a lengthy description of how the brain and intestines function together, one notable example of their importance is that strabismus (when the eyes are not aligned with each other and move quickly back and forth) was cured after conditioning the intestines with good intestinal bacteria. We use a preparation called Bio-Three. This is the trade name of a probiotic product, which contains three active strains of host-friendly bacteria, E.faecalis T-110, C.butyricum TO-A, and B.mesentericus TO-A. Research results have shown that the combination of these three bacteria provides optimal synergistic effects. For more details, please open http://www.bio-three.com/ which is the website of the company that makes this preparation. But you may not able to get it in your country. If so, please try to find any effective probiotics for you by the Internet. You may have to try 3 or 4 probiotics till you can find the best one for your intestine.
Also, try to eat one apple a day. Apple pectin is a good dietary fiber for conditioning the intestines.

* Periodical fasting --- even once in a half year --- brings about really good improvement. It can give a good rest to your intestine. There should be excellent clinics in any countries that offer the course of fasting. Please try to find by Google. You need a professional instructor for fasting. Please don't do it alone.


Mainstream medicine (medicine taught in a university) is not a proponent of a treatment that is critical to maintaining wellness --- detoxification. Great traditional systems of medicine, including classical Chinese, Ayurvedic and Tibetan medicine all believe that before therapeutic medicines are given to patients, the poisonous substances that build up in the body over time should first be detoxified. In contrast, modern medicine, now and in the past, prescribes medicines to patients with no prior detoxification. In fact, it isn’t really a concern to mainstream doctors, a glaring omission in Chinese, Ayurvedic and Tibetan standard medical practices, known in the West as the standard of care. Detoxification is essential for treating psoriasis, as well as many other conditions. It is first necessary to eliminate substances that actually help cause psoriasis. These include heavy metals, toxic chemicals, artificial food additives, remnants of medicines, viruses, bacteria, and others. One of the best ways to detoxify is being in a sauna, especially one using Far Infrared rays. These toxic substances are eliminated in sweat from apocrine and eccrine glands. However, one should not take saunas more than three times a week.
Bbloodletting (phlebotomy) is also very effective for detoxification. Please open http://www.drmakise.com/en/shaketsu/ A warning, which may seem obvious, but should be mentioned anyway, is never to undertake phlebotomy on your own. The procedure should only be done by experienced health professionals in accordance with the particular best practices utilized in each country.

Ultraviolet (UV) Light

UV light, or sunlight, is very effective for treating psoriasis. Solar UV light stimulates the production of vitamin D. 7-dehydrocholesterol (a cholesterol precursor) is found in food and absorbed in the small intestine, where it is converted to vitamin D3 in the skin. In the liver, it is converted to 25 -hydroxyvitamin D3, and is metabolized to 1,25-dihydroxycholecalciferol in the kidney. The latter form of vitamin D3 is most important. Vitamin D3 reduces the overproduction of skin cells that causes scaling, a precursor to skin cancer in some cases. Sunbathing standing by the window is not effective; being outside with the natural rays of the sun is best.
It may take several weeks to see an improvement in your psoriatic lesions. Some people travel even to a tropical zone, an approach well worth trying.
UV light is used as UV blood irradiation therapy, today more commonly called photoluminescence. Blood is drawn from a patient, irradiated, and then injected back into the patient via autotransfusion. This technique has been used to alleviate many diseases, including psoriasis. The treatment is safe and free from adverse side effects. Photoluminescence Therapy (also called Biophotonic Therapy), was first used by Kurt Naswitis in 1922, irradiating blood directly via a shunt. In the 1920s Emmet Knott developed a precursor to the machinery we use today allowing blood could to be irradiated outside the body. He received his patent on September 11, 1928, the same year that he irradiated blood from the first human subject.
The patient had sepsis and recovered within 24 hours post-treatment. By the summer of 1942, more than 6,500 patients had been treated with Photoluminescence Therapy with a greater than 95% success rate, and no deleterious side effects. Despite its efficacy and safety, it is not common in Japan or the United States. To get information about where you can get this treatment in the United States, probably www.acam.org (American College for Advancement in Medicine) may help you.

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