Two important medicines
So, we must eradicate the virus first and modulate the immune system by medicines that have the least side effects. The following two medicines are very important. And the side effects of them are minimal compared with immunosuppressants or biologics.
- Medicine to eradicate the virus. ----> Erythromycin
- Medicine to modulate the immune system. ---> Cepharanthine
Erythromycin (Erythrocin® 200 mg)
Erythromycin is an antibiotic useful for the treatment of a number of bacterial infections. I tried many kinds of antibiotics. But Erythromycin is really good medicine. Theoretically antibiotics is effective against bacteria, but not against virus. Against virus, only anti-viral medicine such as Tamiful against influenza should be effective. But Erythromycin seems to be effective against virus, too, actually. Theory is not reality. Many drugs are effective in theory, but ineffective in reality. Erythromycin is not effective against virus in theory, but it is effective in reality. When I travel oversea by long international flight, I always take Erythromycin since 2 days prior to the flight to prevent bacterial and viral infections. And it does work.
How to take ; 4 tablets/day --- Morning 2 tablets, Evening 2 tablets. But the way of taking is unusual. Please take them as follows.
For 4 days take 4 tablets everyday. And the following 3 days, don't take any tablets. And the next 4 days take 4 tablets everyday, and don't take any tablets for the 3 days. For example, you begin 4 tablets on Sunday. Then on Monday, Tuesday, Wednesday, you should take 4 tablets everyday.
And on Thursday, Friday, Saturday, you should not take any tablets. Then, the next Sunday to Wednesday, take 4 tablets everyday. And on Thursday, Friday, Saturday, you should not take any tablets. --- repeat this cycle for 12 weeks (almost 3 months). *If you are allergic to Macrolides, please don't take this antibiotic.
Cepharanthine ( Cepharanthin® 1 mg)
Cepharanthine is an alkaloid extracted from the plant "Stephania cepharantha Hayata". Cepharanthin® is a rather "obscure" medicine in Japan. It is used only for Alopecia areata and Leukopenia due to radiation therapy for cancers.
Because it is cheap, doctors are not so interested in prescribing it. (Doctors prefer expensive drugs for business!!). And Cepharanthine is getting been forgotten. But we find it is effective for various kinds of diseases. Not only for psoriasis, but also, for example, Multiple Sclerosis, Ulcerative Colitis, Hypothyroidism, Tuberculosis, etc. though we don't know its precise mechanism. Now only one Japanese company produces Cepharanthin. I do hope the company continues its production.
How to take : 3 to 4 tablets/day. Usually you must continue for 3 months. Its side effect is very few. Compared with biologics such as Stelara or immunosuppressants such as MTX, its side effects are almost zero.
Erythromycin: please take at least for 12 weeks (about 3 months) .
Cepharanthine: please take at least for 6 months.
From the 4th month,please take natural supplements that I recommend in this page.
Our special ointments to accelerate cure : PS(1), MAS(1), MA(1)
The ingredients of the ointments.
PS(1) : difluprednate, clofibrate, jojoba oil, vegetable squalene, lanolin hydrous, macadamia nut oil, fermented extract of leaves of shell ginger, very fine powder of 5 kinds of mineral ores.
MAS(1): difluprednate and clobetasol propionate, licorice oil, moringa oil, macadamia nut oil, fermented extract of leaves of shell ginger, vitamin B1, B2, B12, alpha lipoic acid, very fine powder of 5 kinds of mineral ores..
MA(1) : triamcinolone acetonide and clobetasol propionate, moringa oil, macadamia nut oil, vitamin B1, B2, B12, alpha lipoic acid, fermented extract of leaves of shell ginger, very fine powder of 5 kinds of mineral ores..
Although these 3 ointments contain steroidal hormone (corticosteroid), the side effects are really minimal compared to ordinary steroidal ointments.
Thanks to the infrared rays emitted from the fine powder of 5 stones in the ointments your skin is healed quickly. Other than our ointments you cannot find any ointments that emit infrared rays. Having treated more than 40,000 patients with various kinds of skin diseases, we created the formula of our ointments. It took us 15 years to complete them. Our ointments can cure many kinds of difficult eczema due to psoriasis, PPP (pustulosis palmaris et plantaris), atopic dermatitis, nodular prurigo, etc. If our ointments cannot cure the eczema, it is due to fungus, or serious malignancy such as mycosis fungoides (cutaneous T-cell lymphoma).
Both PS(1) and MAS(1) are effective for the treatment of psoriasis vulgaris. But the efficacy seems to depend upon race, climate,foods. For some people with fair and thin skin MAS(1) is more effective. Therefore first I prescribe both PS(1) and MAS(1) and let the patients compare the efficacy for a week. For example, put PS(1) on the lesion of the left side of the body and put MAS(1) on the lesion of the right side of the body. Put the ointment twice a day for a week. Then, you know which is more effective for your case.
For the treatment of guttate psoriasis MA(1) is recommended.
Maintenance Therapy by Natural Supplements
You have now cured psoriasis by the two medicines and our ointment within 4 months. But you should not stop the treatment. You need "Maintenance Therapy" like the case of treatment of leukemia. You should heal your inside problems. But not by chemotherapy. You can prevent the relapse of psoriasis by the following safe natural supplements. From the top, in an important order, I write the essential supplements.
- Probiotics : Please read the Additional Notes.
- Biotin : 15,000 mcg to 30,000 mcg/day
--- Biotin is a kind of vitamin B. Biotin lacks in those patients who are undergoing dialysis, those taking antibiotics, those who take only α - lipoic acid, and people who take very much egg white. Some bodybuilders make protein shakes only by egg white, removing yolk that contains excess cholesterol. If you drink that protein shake everyday, the protein called Avidin in egg white interferes with absorption of biotin from the intestine, because Avidin binds with biotin. And people taking sleeping pills, antidepressants, antiepileptic drugs etc. for a long time also lack biotin. This is very important observation which is often not recognized. Manganese is a vital requirement for biotin to work effectively. (Keep in mind, manganese is rich in pineapple). Manganese is unlikely said to be deficient if you are eating a normal diet. However, intake of calcium in large quantities will inhibit the absorption of manganese. People who take calcium supplements for some reason should take care of this point. Also, manganese is a necessary mineral, especially for lactating women, as it may be rightly called "minerals of love" or "salt of love." As pineapple contains much Manganese, a cup of pineapple juice is recommended.
Because some species of lactic acid bacteria feed on biotin, please don't take large amount of yogurt carelessly.
Dosage of biotin for psoriasis ;10 mg to 15 mg/day. Please do not mistake the unit. It is 10 mg to 15 mg (10,000 mcg to 15,000 mcg), not 10 mcg to 15 mcg (10 μg to 15 μg). Many biotin supplements contain 5000 mcg of biotin per capsule, so in that case, 2-3 capsules per day is recommended. Biotin should be continued for at least 6 months. Smoking should also be quitted as biotin does not work effectively with smoking.
- Omega 3 Unsaturated Fatty Acid : 3000 mg to 4000 mg /day
--- Taking omega-3 unsaturated fatty acids is very important for the treatment of the skin diseases. Because of its anti-inflammatory properties, harp seal oil is useful in treating psoriasis. This could be due to various omega-3 unsaturated fatty acids found in Harp Seal Oil. Harp Seal Oil is recognized as the best source of omega-3 fatty acids, as it contains not only EPA and DHA, but also DPA. About a third of the long-chain omega-3 fatty acids circulating in human blood are the result of DPA, which are the most important essential fatty acid family in maintaining soft, plaque free arterial walls. Harp Seal Oil is also more stable than fish oil, and less vulnerable to the natural process of oxidation.
When omega-3 is in blood stream, they lubricate the cells of the body. This lubrication reduces inflammation and has a healing effect on the cells of the skin. And from EPA, DHA, DPA many beneficial eicosanoids are metabolized. These functions help to alleviate psoriasis.
But if you love such a cute animal as Harp Seal and wouldn't like to sacrifice their lives, please take Sacha Inchi Oil. And If you would like to economize, Flaxseed Oil can be substitute.
- Shell Ginger Supplement ( JIPANG Ginger®) 1400 mg ~ 2000 mg/day ---> http://en.drmakise.com/shellginger/
- Inositol : 750 mg to 1000 mg /day
--- Inositol is a vitamin-like substance contained in cereals a lot. Written as vitamin-like, it is synthesized even though it is very small amount in the body (the exact definition of vitamin refers to substances not synthesized in the body). However, it can be thought that it is a kind of vitamin B group. In our body Inositol is produced from phytin contained in cereals. Phytin, phytic acid (IP6 which is one of them) and Inositol have various actions. Well-known is the control of cholesterol.
Sometimes psoriasis patients suffer from hyperlipidemia (high cholesterol) , and curing it contributes to reducing the severity of psoriasis. Please read Additional Notes of the next page.
Regarding the skin, Inositol relates to the dermal stem cells in the dermis. This dermal stem cell enhances dermis regeneration and repair ability and is working to create healthy skin. Dermal stem cells must be stabilized around blood vessels. And Platelet-Derived Growth Factor (PDGF) is necessary for this. It is Inositol that promotes the expression of the gene of growth factor.
- Zinc : 40 mg/day Zinc Monomethionate or Zinc Picolinate.
--- Zinc is essential for skin regeneration. Regarding skin, it plays an important role in the regeneration of collagen. It is easy to obtain on the Internet or at any vitamin shops. Because it is inexpensive, it is a mineral that everybody can take.
However, if you take too much zinc for a long time, you can not deny the possibility of side effects appearing, so take with caution. Like copper, it is better not to take continuously for a long time.
Also, it is better not to take zinc for those who suffered from hepatitis or those who are carrier of hepatitis virus.
- Copper : 4 mg to 6 mg/day
--- Copper can kill virus. Onset of psoriasis is triggered by virus infection, though main stream medicine doesn't think so.
Copper is cheap supplement and you can get it at any vitamin shops or by the Internet. You should not take copper continuously for a long time. Take for 3 months, but the fourth month you stop it. Then from the fifth month take it for 3 months, and stop it for a month, and take 3 months, --- like this cycle.
- Selenium : 200 mcg/day
--- This mineral is indispensable to glutathione peroxidase enzyme which is very important polymer antioxidant alongside SOD. Selenium is required to make this enzyme. Therefore, when selenium is deficient, naturally, defense against active oxygen and free radicals becomes insufficient.
Selenium also activates thyroid hormone. There are two kinds of thyroid hormones -- triiodothyronine (T3) and tetraiodothyronine (T4). T3 is an active form and can be converted from T4 to T3. For the conversion three enzymes are involved. One of them, type I iodothyronine deiodinase, contains selenocysteine. Selenium is essential for the enzyme to work well. Lack of active thyroid hormone T3 adversely affects psoriasis.
- Magnesium : 200 mg/day Magnesium Glycinate is recommended.
-- It is currently known that 325 kinds of enzymes are directly dependent on magnesium in our body. Therefore, magnesium should be involved with a few thousands physiological reactions totally, if the metabolisms that are indirectly dependent on magnesium are included. In other words, if our body doesn't have sufficient magnesium, our physiological function would get paralyzed.
Omega 3 unsaturated fatty acids are important, as mentioned already. The final metabolites of EPA, DHA, DPA are eicosanoids, and eicosanoids actually exert effects. For that metabolism, enzymes called desaturases are necessary. And magnesium plays an important role to activate desaturases. That's why, if magnesium is insufficient, we cannot get full benefit from supplement of omega 3 unsaturated fatty acids.
And magnesium has detoxification effect of noxious substances. It combines with heavy metals, and the complexes are expelled from the body quickly. Any serious skin diseases are negatively influenced by the accumulation of hazardous substances.
Serum magnesium is not examined by ordinary health examinations. However, ALP (alkaline phosphatase) is often examined. So, if the value of ALP is fairly low, please doubt the lack of magnesium or zinc. Magnesium and zinc are present in the active site of ALP.
Due to hypothyroidism, when you are taking levothyroxine (Thyradin®), take magnesium carefully. Magnesium may weaken the action of levothyroxine.
Nicotine of cigarette or a large amount of alcohol (moderate amount is not a problem) will exhaust magnesium.
When you are taking magnesium, if the stool becomes suddenly soft and diarrhea occurs, it is often caused by magnesium. So, please reduce the intake of magnesium.
- Vitamin K2 as Menatetrenone.
--- Tumor necrosis factor α (TNFα) antagonists play a very important role to alleviate psoriasis. Therefore, some biologics such as infliximab (Remicade®), etanercept (Enbrel®), and adalimumab (Humira®) were produced. But these biologics cause immunosuppression and are contraindicated in patients with chronic leg ulcers, persistent or recurrent chest infections, demyelinating diseases, congestive cardiac failure and malignancy. And very expensive drugs. But safe and cheap vitamin K2 can inhibit the production of TNFα.