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Essential Supplements 7-8

Therapeutic Prescriptions by Vitaminx & Minerals

This is information obtained from Dr. Makise's having cured atopic dermatitis of 40,000 people or more in total and the latest and highest atopic dermatitis treatment. But this is provided for information only. No action should be taken based solely on the contents of this website; instead, readers should consult appropriate health professionals on any matter relating their health. Readers who fail to consult with appropriate health authorities assume the risk of any injuries. Dr. Makise is not responsible for errors or omissions.
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7. Probiotics

It is important to reiterate that the intestine is the body’s largest immune organ. There are many hair-like villi in the small intestine, and in between those villi are Peye’s patches (structured like patchwork). Peyer’s patches is a collection of lymph follicles, and is basically one leading organ that controls the immune system. Also, the epithelium in the small intestine contains 1 lymphocyte for every 5 to 6 epithelium cells, and accounts for 60% of all immune system cells. Aside from that, a Japanese researcher recently discovered lymphoid tissues, which contain undifferentiated lymphocytes called cryptpaches, under the lymph cell of the Lamina propria. This makes T cells unique to the intestines. As a result, it is important to keep the intestines healthy to treat AD.

In addition, the intestines are so linked to the brain that it is called the second brain. It is typically 6 to 7 meters long for Japanese adults, and when spread out, it has the surface area of a whole tennis court. There are almost 100 million nerve cells, which constitutes 50% of all nerve cells in the body aside from the brain. In other words, the brain and intestine control emotions, stress, and sleep together.
Consequently, severe AD symptoms caused by extreme stress and anxiety must be cured by putting the intestines in good shape. Although I cannot elaborate on the functions of the brain and intestines here, one notable example of their importance is when strabismus (squint) was cured just by conditioning the intestines with good intestinal bacteria.

There are over 100 kinds of intestinal bacteria, but I’d particularly like AD patients to take a type of lactic acid bactilli, Miyairi bacteria.
These bacteria are encapsulated in a spore and will go in the intestine without being destroyed by gastric acid. Also, it will exert an anti-inflammation effect by repressing inflammatory cytokine and will not use up biotin, as mentioned before. Some types of bifidobacteria use biotin, so you should stay away from bifidobacteria. There are many types of bifidobacteria, so it is unknown yet which types do use biotin and which ones don’t. Thus, to be on the safe side, you should not eat yogurts with bifidobacteria as an ingredient. It is not good to eat yogurt regularly without knowing what it isn them.

Also, try to eat an apple a day. The fibers in apples, pectin, are good for conditioning the intestines. Instead of eating cake, switch to eating apples, your intestines will thank you.

8. Magnesium 250-300mg/day

More than 325 enzymes directly depend upon magnesium (About 200 enzymes depend upon zinc, around 20 enzymes depend upon copper, and 10 upon selenium) to function properly. So, including metabolic pathways indirectly depending upon magnesium, a few thousands of chemical reactions in the body need magnesium. If we didn't have sufficient magnesium, physical functions including skin would paralyze.

We discussed a lot about omega 3 unsaturated fatty acid and omega 6 unsaturated fatty acid. Magnesium is deeply involved with the metabolism of these unsaturated fatty acids. Desturase which metabolizes unsaturated fatty acids to eicosanoids need magnesium along with vitamin B3, vitamin B6, vitamin C, and zinc. Therefore, insufficiency of magnesium intake makes flax seed oil useless. And magnesium has detoxification effect of toxic substances. It is combined with heavy metals and it quickly eliminates them from the body.

Recently foods are too much refined and terribly deficient in magnesium compared with foods in other times. And we don't have mechanism to store magnesium in out body. Besides, recent high fat diet prevents the intestine from absorbing magnesium, and high protein diet eliminates magnesium fast from the body. In other words, a lot of people lack magnesium.

AD is often associated with asthma, and theophylline which is bronchodilator agent is prescribed. But theophylline has effect of depletion of magnesium. Some patients face bullying and take anti-depression medicine such as SSRI (Selective Serotonin Reuptake Inhibitors). This kind of anti-depression medicines contain fluorine, and that fluorine is bound with magnesium, resulting in the insufficient work of magnesium.
And AD itself brings about mental stress to the patients, and adrenaline increases. Increasing adrenaline depletes magnesium and many AD patients lack magnesium. If the symptoms of AD is so serious that the patients can not help taking oral steroid medicine, that steroid depletes magnesium. Hyperthyroidism and diabetes mellitus also deplete magnesium.

Very few doctors recognize this fact, and usually serum magnesium is not checked at least when you go to hospital or clinic for AD. Because, as I write here, magnesium is involved directly and indirectly with thousands of metabolic pathways, this neglect of magnesium is one of the fatal mistakes of modern medicine.
 
And even if magnesium is checked, it is the magnesium in the plasma. But plasma magnesium is at most only 1 % of total magnesium in the body.
And when our body is exposed to stress, our body takes out magnesium from the cells and send it to the blood. So, in spite of insufficiency of magnesium totally, serum magnesium check gives us misinformation that the level of magnesium is normal.

AD patients should not eat Chocolate, because the beans and oils used in chocolate aggravate the symptoms. But especially AD patients love chocolate. Probably it is because chocolate contains much magnesium. AD patients seem to know it by instinct and they want magnesium. If the beans and oils used in chocolate were safe for AD patients, we would like to recommend them to take. But unfortunately not so. It is a pity.

If you drink soy milk every day, please be careful. Soy contains phytic acid most among beans. Phytic acid is bound with magnesium and it prevents magnesium from being absorbed. (But fermented soy such as miso is not problem). And brown rice contains lot of phytic acid, and be careful. Nicotine of tobacco, and large consumption of alcohol ( if moderate, no problem) deplete magnesium.

Per 1 kg of body weight, 6-8 mg of magnesium is adequate. For children who grow quickly, it is said that 10 mg of magnesium per 1 kg of body weight is necessary. But we take magnesium from food and hard water, too, from supplement 250 mg- 300 mg should be OK. Nuts and green and yellow vegetables contain magnesium a lot. And kelp, too.

If you take magnesium a lot at once, it may evoke diarrhea. So, please take small amount till your intestine gets used to magnesium.
You can find many kinds of cheep magnesium in Internet. We recommend magnesium glycinate.


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