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Insidious Hypothyroidism (3/5)

 

3) Estrogenic Hypothyroidism

And " Estrogen Dominance" complicates the problem of thyroid problems. If you are on hormone replacement therapy to alleviate your menopausal syndrome, sometimes estrogen is given slightly more than necessary because of insufficient medical follow-up. This extra estrogen increases the Thyroxine-Binding Globulin (TBG). TBG absorbs thyroid hormone flowing freely in bloodstream as it is a protein that can bind to thyroid hormone even in normal condition. This decreases the functional thyroid hormones in body. In this case, even if your thyroid function itself is OK, you would suffer from hypothyroidism.

And now our modern world itself has become "Estrogen Dominant" due to endocrine disrupters, or environmental hormones. One of the typical instances is dioxin. This is a very troublesome substance that is produced when burning vinyl chloride or vinylidene chloride which is used anywhere and once it is taken into the body it hardly goes out. Previously it was thought that the influence of dioxin is related only to the occurrence of cancer and neonatal malformation. But the subsequent studies have elucidated that this evil substance also acts like estrogen. It works in units of picogram(=10-12g). Rather difficult for us to grasp this so minute unit. But image of one droplet of dropper in the 50 meter pool makes us understand easily the relationship of this substance and our environment.
However, environmental hormone is not only dioxin, but it is also contained in insecticides, industrial wastes, automobile exhaust gases, soaps and shampoos, nail polish, paints of furniture and building materials. Moreover, most of it shows estrogenic effects in units of one trillionth to one billionth gram. In other words, we live in the ocean of estrogen from childhood, or more precisely, we are exposed to excessive estrogen from the time of fetus.

In addition, estrogen enters our body from foods. Please check especially beef. If the cow is brought up by being fed hormones, the beef might contain much estrogen.

And obesity causes "Estrogen Dominance". We are living in "Obesogenic Society". Too much sugar intake, too much fat consumption, less mobility by cars, sedentary lifestyle in front of computer are big factors of "Obese Genesis". Now we have more fat cells, exactly speaking, white adipose (fat) cells than before. In the white adipose cells androstenedione is converted to estrogen (androstenedione--> estrone--> estradiol--> estriol).
Consequently both women and men are confronting increased Thyroxine-Binding Globulin (TBG), which may cause very mild hypothyroidism with apparently normal level of T3 and T4.

And if your liver function is weak due to excess intake of alcohol, or fatty liver, estrogen cannot be well metabolized in the liver. This induces "Estrogen Dominance", too, in our body.

Nowadays, in our "Estrogen Dominant" world, we may suffer from very mild hypothyroidism without noticing. About 1 in 20 people may be suffering from this Estrogenic Hypothyroidism despite thyroid hormones themselves being fully secreted.


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