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Is Cholesterol a Villain? (3/5)

 

Cholesterol is absolutely necessary for physiological functions.

Metabolic map

Cholesterol is absolutely essential for the human body. Sex hormones such as testosterone and estrogen that are mainly produced in the testicles and the ovaries cannot be produced without cholesterol. Therefore, if you start taking antihyperlipidemic drugs, sexual performance may suddenly become weakened. In most cases, neither patients nor doctors do notice that it is due to the drugs. Instead, they think it is due to aging.

The skin receives ultraviolet rays and produces vitamin D from cholesterol. Steroid hormones that are produced in the adrenal glands are also derived from cholesterol. And cholesterol is an important factor constituting the cell membrane.

People with low cholesterol have a strong tendency to suicide.
(Low serum cholesterol and suicide: The Lancet Volume 339, Issue 8795, 21 March 1992, Pages 727-729)
(Hypothesis: Low Serum Cholesterol, Suicide, and lnterleukin-2:Am J Epidemiol (1995) 141 (8): 716-718. )

Also, according to a study by Leiden University in the Netherlands, it has been proved that in the case of 85 years of age or older, the higher the cholesterol, the lower the rate of infectious disease and cancer, and consequently they can live longer.
(Total cholesterol and risk of mortality in the oldest old. The Lancet Volume 350, Issue 9085, 18 October 1997, Pages 1119–1123)

Therefore, it is quite nonsense itself to struggle to reduce forcibly cholesterol by
antihyperlipidemic drugs that have a lot of side effects. Cholesterol has got reduced and the danger of CHD got reduced a few percentage, but it doesn't make any sense if we get sick by other diseases than CHD. What is the most important is that we must be careful of the oxidization of cholesterol. We must prevent cholesterol and triglyceride from oxidization and glycation by proper antioxidants and supplements that have anti-glycation effects. And also vitamin B6, vitamin B12, folate are recommended, because they reduce homocysteine level.

After all, cholesterol is OK as it is!!

That's why I don't prescribe any antihyperlipidemic drugs to lower cholesterol, no matter high their level, unless the patient suffers from Familial Hypercholesterolemia,
But, if LDL is very high, in the case of above 190 mg/dl, I recommend the patient to take natural supplements to prevent its oxidation.
And those who are suffering from serious hypertension, or serious diabetes, or had already suffered from CHD with high LDL should take statin drugs.
And also the patient with Familial Hypercholesterolemia (FH) whose total cholesterol level is higher than 350 mg/dl, triglyceride is higher than 900 mg/dl, should take statin drugs. FH occurs in 1:500 people. In the case of FH patients, yellowish patches consisting of cholesterol deposits (xanthelasma palpebrarum) above the eyelids are often observed.

Cholesterol level increases in cases of hypothyroidism, kidney disease, too. And the side effect of some drugs causes high cholesterol. For these cases, of course, the treatment of the causative disease is necessary.


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